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10.1016/j.phymed.2019.152860 18 CaoX.XiaoH.ZhangY.ZouL.ChuY.ChuX

AAV-mediated acute knockdown of Gpr146 confirms its role in promoting hepatic steatosis and adiposity To further validate the regulatory role of GPR146 in hepatic lipid accumulation and to rule out the possibility that the phenotypes observed in germline knockout mice result from developmental compensation, we employed an AAV-mediated approach to acutely knock down Gpr146 in adult mice