e3 ubiquitin ligases mitophagy copd smoking or cigarette smoke Schematic diagram shows that induces mitochondrial PRKN Ser131 phosphorylation promotes cigarette

PRKN Ser131 phosphorylation promotes cigarette smoke induced mitophagy impairment and epithelial cell senescence via MKK3 p38 MAPK activation: An in vitro and in vivo study Full article: Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease Frontiers Emerging role of selective autophagy in human diseases Frontiers Cigarette Smoke Reduces Fatty Acid Catabolism, Leading to Apoptosis in Lung Endothelial Cells: Implication for Pathogenesis of COPD

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