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On the other hand, the action of 15-LOX leads to the metabolism of 15-HpETE to eoxin A4 (EXA 4 ) [108], which, analogous to the biosynthesis of leukotrienes, is conjugated with glutathione, forming eoxins C4, D4, and E4 (EXC 4 -EXE 4 ) [129]

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It has been demonstrated that dysregulation of the Hippo pathway leads to abnormal activation of its downstream transcriptional co-activators Yes-Associated Protein (YAP)/Transcriptional Co-activator with PDZ-binding motif (TAZ), promoting excessive keratinocyte proliferation

F Immunoblot assay of apoptosis-related proteins (Cleaved-Caspase 9, Cleaved-Caspase 3, Bcl-2 and BAX) in BPH-1 and WPMY-1 after GPX3 overexpression or U0126 treatment