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Mice may suffer from the painful conditions that are induced to recreate the human disease or condition Key anatomical differences between humans and rodents may impact inhalation data transferability The smoke inhalation model of COPD simply creates respiratory conditions which are indicative of inhalation toxicity, chronic stress, and lung injury rather than COPD and is an invalid method The smoking habits of humans are not represented in animal models There are more sophisticated human-based inhalation models available to provide results of greater human relevance What could researchers be doing differently