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More recently, various mutations have been discovered that influence the central enzymes of the methylation cycle the MTHFR mutation has already been discussed in this context

F., Peng, J., Xie, Z

In particular, the v3 integrin can be activated by shear stress (Tzima et al., 2001) making it likely to be activated on SC cells when shear stress is increased ( Transforming growth factor 2 (TGF2), which is a risk factor for primary open angle glaucoma (POAG) (Fuchshofer and Tamm, 2012), increases expression of both v and 3 integrin subunits (Tsukamoto et al., 2018)