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Milk thistle is best reserved for use when the liver is already under abnormal stress. You can find milk thistle in tincture (liquid) or powder form at most health food stores

6,596,701, references that replacement of deficiencies of the constituent components related to the formation of S-adenosyl methionine will aid in the restoration of health related problems, but there is no reference for the use of the combination of glutathione alone or in combination with methylcobalamin to restore the function of the methionine cycle

Nagel AK, Ball LE

They report results on human carotid artery ECs, and THP-1 monocyte cells (a spontaneously immortalized monocyte-like cell line), which show that ET-1 and its receptors are expressed in the macrophages and ECs of human carotid plaques