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Glutamate toxicity can also trigger calcium influx that leads to mitochondrial calcium overload [12] whereas, once fragmented, mitochondria reduce their calcium buffering capacity [49]

Ceramosides Phytoceramides for Moisture Retention: Ceramides are lipid molecules that form 50% of skin's outer layer

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Notably, the treachery of MANF, an initial liver protective factor, in ICC is a representative regulatory mechanism of body, which opens the doors for potential diagnosis and treatment of ICC (Fig