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3.2.7 Luteolin Luteolin (3,4,5,7-Tetrahydroxyflavone) is a flavone aglycone that is present in Perilla frutescens (L.) Britton [Lamiaceae], and exhibit a wide range of pharmacological activities, such as antioxidant, anti-inflammatory, anti-cancer, and immunomodulatory activities ( in vivo reduced IgE and IgG levels, increased IgG2 levels in the serum, increased IFN- and IL-17 cytokine levels, and reduced IL-4 and IL-10 levels in the spleen tissue

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

doi: 10.1016/j.taap.2009.11.028 84 Abd El AzeemRAZedanMMSaadEAMutawiTMAttiaZR

Chronic sensory deprivation by whisker trimming induces a net decrease in the number of symmetric GABAergic synapses in the dendrites of layer 4 neurons of barrel cortex, the main target neurons for the thalamocortical axons relaying sensory information from the whiskers (Micheva and Beaulieu, 1995)