glutathione dehydrogenase function Glutathione transferases: substrates, inihibitors and

Notation of interest: Methylcobalamin B12, is often considered beneficial for individuals with Methylenetetrahydrofolate reductase (MTHFR) gene mutation

Enhances Vitamin Recycling Helps regenerate essential vitamins E and C for improved wellness

Forms studied: Dihexa has been tested in oral formulations and subcutaneous injections

TGR inhibitors do not react covalently with GSH, selenocysteine, or TGR, and inhibition of TGR is reversible To evaluate stability of the TGR inhibitors in the presence of GSH and selenocysteine, compound 2 and a known covalent inhibitor of TGR, TRi-1 20,45 , were incubated with GSH or the N-Boc protected methyl ester of selenocysteine, and the reaction mixtures were analyzed by LCMS (Supplementary Figs