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Reactive oxygen species, cytokines, and axonal damage in multiple sclerosis Mechanisms of axonal damage are the consequence of the presence of TNF, matrix metalloproteinases (MMPs), ROS, antibodies, increased glutamate, and aspartate, and these molecules cause excitotoxicity in MS patients

Clarkson, B, Gee T, Arlin Z, Mertelsmann R, Kempin S, Dinsmore R, O'Reilly R, Andreeff M , Berman E, Higgins C, Little C, Cirrincione C, Ellis S

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Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets