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WD and lipid dysregulation The chief pathological feature of WD was significant hepatic steatosis, with hepatic copper levels positively correlating with the degree of steatosis[136]

80 Next, firm adhesion is mediated through, for example, the macrophage antigen-1 (Mac-1/CD11b) expressed on neutrophils and its ligand ICAM-1 expressed on the endothelium

When cataracts form in newborns, they are often associated with mutations in proteins involved in metabolic pathways related to the metabolism of a sugar called galactose, while mutations in structural proteins like crystallins occur frequently in childhood cataracts (Churchill 2011