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Lee, K., Lee, J., Ryu, S

Their structural adaptability allows for precise modulation of release kinetics, targeting, and protection against degradation

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Drug resistance also has been reversed by addition of non-antibiotics such as phenothiazines and chlorpromazine to an antibiotic to which the bacteria are initially resistant.19 Amlodipine has been reported to have the most powerful antibacterial activity among cardiovascular non-antibiotics.11In vitro studies also suggested that dihydropyridine calcium antagonists act as antioxidants and reduce leukocyte-induced oxidation of low density lipoproteins.28 AML also has been suggested to improve endothelial dysfunction in diabetes through antioxidant and anti-inflammatory mechanisms.29 It has been shown to act synergistically with antibiotics and to have in vivo and in vitro antimicrobial activity against several bacteria.25 In our study, histopathological examination showed that AML improved lamina propria edema, collagen deposition, decreased ciliary loss compared to saline treated and cefazolin treated groups