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1 Introduction Pediatric low-grade glioma (pLGG, WHO grade 1 or 2) is the most common brain tumor class in children ( 2 Molecular landscape of pLGG Advances in sequencing technologies have aided in classifying the diverse spectrum of pLGG histopathology

The sulfhydryl group (-SH) on glutathione's cysteine residue binds directly to heavy metals including mercury, lead, cadmium, and arsenic, forming glutathione-metal conjugates that can be excreted through bile and ultimately eliminated from the body

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WD is caused by mutations in ATP7B , which encodes a transmembrane copper-transporting ATPase, leading to impaired copper homeostasis and copper overload in the liver, brain and other organs