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The epigenetic study has found that Hcy induces DNA hypomethylation of the cyclin A promoter by downregulating the expression of DNA methyltransferase 1 (DNMT1) to inhibit endothelial progenitor cells (EPCs) proliferation (108)

This work was supported by the Lions Eye Institute Flow Cytometry and Histology facilities and by the following Monash University platforms: Monash Animal Research Platform, Monash Macromolecular Crystallization Facility, FlowCore, Monash Micro Imaging, and Monash Histology

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