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They are most effective when taken 12 hours before injection in patients with a known history of mild allergic responses

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Activation of the NF-B pathway further promotes NLRP3 transcription and inflammatory cytokines such as TNF- and IL-6, impairing renal vascular cells [76, 114]

Johns wort carries a number of known side effects, including increased sensitivity to sun, making both the skin and the eyes more susceptible to sun damage