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doi:10.1080/1028415x.2019.1701220 Vitellio P, Chira A, De Angelis M, Dumitrascu DL, Portincasa P

DOI: Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-71519-9 Online ISBN: 978-3-030-71519-9 eBook Packages: Living Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established

Ipamorelin acts on a separate receptor (GHSR rather than GHRHR), which is why researchers studying the GH axis frequently administer a GHRH analog and a ghrelin mimetic together see the CJC-1295 + Ipamorelin blend for a combined-compound research format