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Renal clearance plays a central role in Phase 3 detoxification, particularly for small, polar compounds

Cell lines Hucct1, RBE, and AML12 cell lines were purchased from Procell with short tandem repeat (STR) identification and cultured in RPMI 1640 (Hucct1 and RBE) with 10% fetal bovine serum or DMEM/F12 (AML12) with 10% fetal bovine serum, 1ITS-G, 40 ng/mL dexamethasone in incubator (37 C, 5% CO 2 )

Neurological functions Several neurological diseases, such as Alzheimers disease and Parkinsons disease, are characterized by disrupted metabolism of the redox-active metals copper and/or iron and/or non-redox zinc (Simunkova et al

10.3390/ijerph16050757 28 RavandiF.KoumenisI.JohriA.TallmanM.RobozG