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However, the axiomatic statement (direct damage to cell), pointed already for standard cytoprotective agents, prostaglandins, somatostatin, and sulfhydryls (29-34), verifies such prototype of cytoprotection lesion (surgical perforation as a direct harmful effect) (35-37)

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Interestingly, animals like salamanders and axolotl are able to regenerate entire limbs, and this regenerative process is driven primarily by hematopoietic and myeloid stem cells, which in the human is the equivalent of bone marrow stem cells that drive mesenchymal cell lineages of ligament, cartilage, muscle, bone, and connective tissues [52]

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