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Description

Colony formation assays indicated that colonies formed by the IDH1 WT/Mut group were smaller than those of the IDH1 WT/WT group, suggesting that the IDH1-R132H mutation significantly inhibits tubular epithelial cell proliferation (Fig

175,176 STATs are phosphorylated and translocated into the nuclear compartment to transcriptionally upregulate specific genes, 177 often leading to cell proliferation or differentiation