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(2024) CNS Neuroscience & Therapeutics , 30(3): e14676 Confirmed ARA-290 provides neuroprotection in a mouse MCAO cerebral ischaemia model via CR, significantly reducing neuronal apoptosis and inflammatory cytokines, equivalent to EPO neuroprotection but without erythropoietic side effects

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In children, increased iron deposition is observed in the basal ganglia, thalamus, and periventricular white matter after severe hypoxicischemic injury (130), reinforcing the role of disrupted iron homeostasis in ferroptosis and stroke pathology