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When norepinephrine is released into the synapse between neurons, the amount of norepinephrine available there is controlled by the norepinephrine transporter, NET.[ref] In POTS, research points to an excess of norepinephrine signaling, and this could be due to decreased NET activity, essentially allowing too much norepinephrine to remain in the synapse

Proper injection technique, including rotation of injection sites and allowing the medication to reach room temperature before administration, may help minimize these local reactions

Originally its delivery form was limited to capsules and tablets, but subsequently a sublingual (i.e

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