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204 The accumulation of the hyperphosphorylated tau protein, a type of microtubule-associated protein (MAP), induces the formation of neurofibrillary tangles, and the aggregation of the amyloid-beta 1-42 (A42) fragment produced from APP results in the formation of senile plaques by disturbing the activity of PS1 and PS2

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When compared with systemic treatments, this approach would have clear dose-sparing and precision targeting potential, since the lymphatic drainage will carry peri- or intratumorally injected therapeutic antibodies by default to the same LNs, which drain the metastatic cells escaping from the primary tumor