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Although it is unclear how Nexium affects the kidneys, the extended use of Nexium has been found to cause severe kidney problems like Acute Interstitial Nephritis (AIN)

1 Neuropathic pain is present in a significant subset of patients

In addition to NAD + , CD38 also catabolizes nicotinamide mononucleotide (NMN) and other extracellular NAD + precursors prior to their intracellular transport for NAD + biosynthesis (Fig