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This beneficial effect was attributed to a plethora of mechanisms, including (i) improved enzymatic antioxidant system capacity with a concomitant decline in the level of lipid peroxidation, (ii) increase in activity of glutathione S-transferase, (iii) downregulation of glucose transporter 1 (GLUT1) restoring normal declined blood glucose levels in tumor cells, (iv) inhibition of lactate dehydrogenase dependent glycolytic machinery, (v) vasodilation of blood vessels resulting in decreased tumor hypoxia and downregulation of the angiogenesis markers

Lastly, applications of GST inhibitors in targeting cell signaling pathways and intracellular biological processes are discussed, and the potential for disease treatment is prospected

Furthermore, reduced levels of cell membrane HA and impaired renewal capacity have been observed in AECs from subjects with severe lung fibrosis [300]

Astaxanthin merupakan pigmen alami (karotenoid) yang dikenal memiliki aktivitas antioksidan yang dapat membantu menetralisir radikal bebas