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Mitophagy in PDAC PDAC cells display prominent mitochondrial alterations, including elevated mtDNA mutation rates, enhanced mitochondrial fragmentation, and increased fission activity compared to normal pancreatic tissues [14, 15]

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Eur Heart J 26:21422147 Grundy SM, Howard B, Smith S Jr, Eckel R, Redberg R, Bonow RO (2002) Prevention Conference VI: Diabetes and cardiovascular disease

Similarly, serotonin and dopamine influence the brains arousal and seizure susceptibility, with altered activity in these systems being linked to epilepsy