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The first clinical trial, titled A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of BG00012 in Combination with Methotrexate in Patients with Active RA Who Have Inadequate Response to Conventional Disease-Modifying Anti-Rheumatic Drug Therapy (NCT00810836, 20012010), was initiated by Biogen and involved 153 participants

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(20) conducted a study on mice, revealing that oxidative stress damage in aged oocytes results in diminished expression of protein phosphatase 2A (PP2A) at the centromere, reduced dephosphorylation of the Rec8 protein, compromised protection mechanisms of adhesion proteins within the oocyte, inhibition of oocyte division and maturation, and the emergence of aneuploidy