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First-pass metabolism : Higher hepatic exposure from oral delivery theoretically increases liver burden, though clinical significance remains unclear for most peptides at research doses

Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review

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However, the expanding toolkit of VLP engineering strategiesspanning genetic fusion, modular conjugation, and nucleic acid encapsulationcreates a critical need for a rational selection framework to match technological strengths with specific vaccine objectives