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Graphical Abstract The graphical abstract depicts an overview of the pathways involved in the emergence of morphine-related tolerance and dependence including NMDA, Nitric oxide, and PPAR, as well as behavioural sensitization along with present and future innovative treatment strategies including stem cell therapy that have been discussed in the current manuscript

Although not FDA-approved, enclomiphene has been evaluated in several studies for men with secondary hypogonadism

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FIGURE 1 Neutral lipids stored in LDs are primarily degraded by two pathways: lipophagy and lipolysis