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Arch Gen Psychiatry (2004) 61:97484.10.1001/archpsyc.61.10.974 71 GeorgiBCraigDKemberRLLiuWLindquistINasserSet alGenomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate

GlyNAC supplementation differentiates itself as a physiologic approach to correct glutathione deficiency, because it harnesses the cellular regulation of glutathione synthesis and reduces the risk of reductive stress, a phenomenon where excessive antioxidant intake pushes oxidation too low and disrupts normal cellular signaling

All forms of aerobic life are thus faced with the threat of oxidation from atmospheric molecular oxygen and have developed elaborate mechanisms of antioxidant defenses to cope with this potential problem [2, 3, 1618, 22, 26]

doi: 10.1126/science.aat5236 60 KaufmannS