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Additionally, copper disrupts the ubiquitin-proteasome system and inhibits cellular protease activity by interfering with cell proliferation

Thus, CrP is mainly considered as energy buffer for emergency situations [55, 133]

(eds) Optimization in Drug Discovery

The phosphorylation of IKK at Ser177 and Ser181 promotes the IB phosphorylation to trigger the ubiquitination and degradation of the latter to worsen the NF-B cascade [3, 8, 9]