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Artemisinin could induce the phosphorylation of cAMP response element-binding protein (CREB) via the activation of p38 MAPK signaling in osteosarcoma cells, and the phosphorylation of CREB can also bond specifically to the promoter of secretion of thrombospondin-1 (TSP-1) and promote its transcriptional activation, suggest the p38 MAPK/CREB/TSP-1 signaling cascade might be a potential therapeutic target for osteosarcoma

J Cell Sci 89:2538 Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G et al (2021) Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry