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Crizotinib versus chemotherapy in advanced ALK-positive lung cancer

When SAM-e loses a methyl group, it becomes SAH (s-adenosyl-homocysteine), which then is hydrolyzed to form homocysteine.[ref] This is called the methylation cycle or the methionine cycle

These results demonstrate a less coordinated response and emphasize the importance of these pathways in determining cultivar-specific resistance or susceptibility to pathogen attack