Price VH, Hordinsky MK, Olsen EA, Roberts JL, Siegfried EC, Rafal ES, Korman NJ, Altrabulsi B, Leung HM, Garovoy MR, Caro I, Whiting DA (2008) Subcutaneous efalizumab is not effective in the treatment of alopecia areata

Abbreviations Ahp alkyl hydroperoxide reductase APS 5-adenylylsulfate BSO buthionine sulfoximine CoA coenzyme A Cys Cysteine EGFR epidermal growth factor receptor ER endoplasmic reticulum FTR ferredoxin-thioredoxin reductase Gpx glutathione peroxidase Grx Glutaredoxin GSH reduced glutathione Gsr glutathione reductase GSSG oxidized glutathione, glutathione-disulfide Hcy Homocysteine LA lipoic Acid Lpd lipoic acid dehydrogenase Met Methionine Msr methionine-sulfoxide reductase NAD + nicotinamide adenine dinucleotide, oxidized NADH nicotinamide adenine dinucleotide, reduced NADP + nicotinamide adenine dinucleotide phosphate, oxidized NADPH nicotinamide adenine dinucleotide phosphate, reduced NOX NADPH-oxidase Nrf2 nuclear factor erythroid-2-related-2 PAPS 3-phosphoadenosine-5-phosphosulfate PDGFR platelet-derived growth factor receptor PPG Propargylglycine Prx Peroxiredoxin RNR ribonucleotide reductase ROS reactive oxygen species S Sulfur SAH S -adenosyl homocysteine SAM S -adenosyl methionine Se Selenium Sec Selenocysteine TCA tricarboxylic acid cycle Tgr thioredoxin-glutathione reductase TRP14 thioredoxin-related protein of 14 kDa Trx Thioredoxin TrxR thioredoxin reductase Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

47,48 PGD is also hyperactive and plays a fundamental role in tumor growth
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