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APAP-induced hepatotoxicity is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1 (CYP2E1)

Furthermore, the M1 macrophages mediate their anti-microbial activity through the activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and the subsequent production of reactive oxygen species (Shapouri-Moghaddam et al., 2018)